Advantages of using PGD in IVF cycles
Preimplantation genetic diagnosis improves your chances of delivering a healthy baby.
This is the method, which allows to conduct full examination or screening of embryo’s genome before transferring it to its expectant mother. This is the way how only healthy embryos are chosen for expectant mother. In addition, specialists of Intersono IVF clinic can prevent diseases, which were caused by changes in genetic material (damage of chromosome number or separate gene mutations) using this method.
First successful labour after similar procedure took place in 1990. In the same year there was performed a diagnostic of some diseases before fertilization, and in 1992 the first child was born after diagnosis of serious hereditary disease of the respiratory tract.
What is preimplantation genetic diagnosis used for?
Preimplantation genetic diagnosis allows to prevent birth of children with gene mutations, which can lead to number of diseases, in particular cystic fibrosis, Tay-Sachs disease, sickle cell anemia, hemophilia A, Duchenne’s muscle dystrophy. In case of increased risk probability of child with congenital anomalies, birth the preimplantation genetic diagnosis of nine chromosomes is conducted. Changes in these chromosomes can lead to appearance of Patau's syndrome, Prader-Willi syndrome, Edwards syndrome, Down syndrome, Turner syndrome and Klinefelter's syndrome.
It is also important to understand that embryos genetic analysis also conducts to prevent rhesus incompatibility between mother and child.
Embryos genetic analysis can be performed on the stage of embryo cleavage (6-10 blastomeres), namely on the 5th day of its existence. To do this, we use laser to make a hole in embryo’s veil, and then through this hole sampling of cells from the embryo is performed with special needle for biopsy. Received cells are placed in special test tubes for genetic analysis and are sent to the laboratory for further work. Sometimes to perform more accurate diagnostic there is a need in samples of biological material (blood) of future parents and close relatives.
All the process of analysis takes about 48 hours, after what embryologists get all detailed information about genetic material of each embryo.
GENETIC ANALYSIS FOR FUTURE PARENTS.
Man and woman, who are going to become parents, also can have a preimplantation genetic diagnosis at Intersono IVF clinic. Sample of blood or tissue should be submitted for genetic research. After submitting a sample for medical history, geneticists check it during next 48 hours and then they can evaluate the condition of parents and their genetic health.
The ability of before pregnancy diagnosis is the main advantage of preimplantation genetic diagnostic. It minimizes risk of fetation interruption because of genetic reasons.
Who should be diagnosed by PGD?
- Women, who are older than 34. With aging women’s eggs growing old what means that gene mutations and damage the integrity of the genetic material arise more often and as a result, frequency of occurrence of embryos with damaged genotype is increased.
- Women with recurrent miscarriage. It can be connected with abnormal chromosome complement in man or woman’s gametal cells.
- Couples with autosomal dominant disease or people who has changes of configuration of chromosomes.
- Couples with repeated failure of IVF (in vitro fertilization)
- Couples, who are related to group of risk when child would born with terminal disease.
We cannot prevent genetic disease if it is already exist. Genetic disease cannot be treated as a whole, only symptoms can be treated. However, the analysis, which our clinic offers, allows to choose only healthy embryos, what means that sick embryo will not be transferred. That is why it guarantees that you and your child will have healthy, happy and carefree childhood.